Tumacácori sits at a cultural crossroads in the Santa Cruz River valley, and is where O'odham, Yaqui, and Apache people mixed with Europeans.
From his arrival in the Pimería Alta in 1687 until his death in 1711, Padre Kino established over twenty missions. The Jesuit missionaries administered them until the time of their expulsion in 1767. From 1768 until after Mexico got her independence in 1821 the missions were operated by the Franciscan missionaries. Some are still in use today while others have fallen into ruin.
Tumacácori National Historical Park in the upper Santa Cruz River Valley of southern Arizona is comprised of the abandoned ruins of three of these ancient Spanish colonial missions. San Jos de Tumacácori and Los Santos Angeles de Guevavi, established in 1691, are the two oldest missions in Arizona. San Cayetano de Calabazas, was established in 1756.